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ea0042oc2 | (1) | Androgens2016

Control of androgen bioactivity by sex hormone-binding globulin

Laurent Michael R , Antonio Leen , Blokland Marco H , Sterk Saskia S , Jardi Ferran , Dubois V , Kaufman Jean-Mark , Fiers Tom , Huhtaniemi Ilpo T , Hammond Geoffrey T. , Vanderschueren Dirk , Claessens Frank

Sex hormone-binding globulin (SHBG) is a high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG regulates the free sex steroid fraction and restricts androgen bioactivity. SHBG has also been independently associated with diabetes, osteoporosis etc., but whether this represents causality or residual confounding remains unconfirmed. We studied mice overexpressing human SHBG. Using multiligand liquid chromatography ta...

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ea0037gp.08.01 | Reproduction: Male and endocrine disruptors | ECE2015

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

Ahern Tomas B , Huhtaniemi Ilpo T , Carter Emma L , Finn Joseph D , Pye Stephen R , O'Neill Terence W , Bartfai Gyorgy , Casanueva Felipe F , Forti Gianni , Giwercman Aleksander , Han Thang S , Kula Krzysztof , Lean Michael EJ , Pendleton Neil , Punab Margus , Vanderschueren Dirk , Wu Frederick C W

Introduction: Primary hypogonadism (PHG, testosterone <10.5 nmol/l and LH >9.5 U/l) without a recognisable cause affects ~2% of community-dwelling middle-aged and older men. We sought to identify the clinical significance of, and risk factors for, this apparently age-related hypogonadal state.Methods/design: The European Male Ageing Study (EMAS) is a prospective observational cohort survey of 3.369 community-dwelling men aged 4079 in eight ...

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Endocrine Abstracts

Control of androgen bioactivity by sex hormone-binding globulin

Characteristics and predictors of primary hypogonadism in ageing men: longitudinal data from the European Male Ageing Study

BiosciAbstracts